Pharmacology

Pharmacology

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    Pharmacology Assignment HelpPharmacology Homework Help

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    Pharmacology:

    It studies drug concerns with drug action, side effects, drug discovery, therapeutic index, uses the mechanism of action, etc. Majorly it is divided into two categories: pharmacokinetics and pharmacodynamics.

    Pharmacokinetics: it involves the biotransformation of the drug by body actions. There are four processes in which the drug’s metabolism takes place: absorption, distribution, metabolism, and excretion.

    Absorption means how much administered drug reach into the bloodstream.

    Distribution tells the movement of the administered drug to various organs and tissues by blood flow.

    Metabolism includes the degradation of drugs by using enzymes.

    Excretion comprises drug removal from the body.

    Pharmacodynamics: Action shown by the drug in the body after administration.

    Bioavailability measures the extent to which the administered drug is available to the systemic circulation in its original state.

    Applications:

    • It helps collect data for clinical trials and use it to obtain a new drug molecule.
    • It tells us about various interactions of drugs, side effects, and their therapeutic window.
    • Correlate whether two different drugs show the same effect or the opposite, which helps us categorize drugs.
    • Provide assessment of the action of drugs on a diseased state or healthy patient.
    • It provides the most relevant data regarding the dose and dosage form.

    Disadvantage:

    • After so many trials, sometimes drug show interaction with other drugs, safety issues, and ADRs, which leads to withdrawal of molecules from the market.
    • Due to clinical trials, it consumes much time to take a drug into the market.
    • The low therapeutic index of the drug leads to a problematic condition.
    • Drug-drug interaction or drug polymorphism leads to the degradation of the desired molecule and its therapeutic action.
    • Individualization of the dose is required, but it can increase cost, which is trouble for drug discovery of molecules.

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