Pharmacology

Pharmacology

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    Pharmacology Homework Help

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    Pharmacology Assignment Help

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    Pharmacology:

    It is a study of drug concerns with drug action, side effects, drug discovery, therapeutic index, uses, and mechanism of action etc. Majorly it is divided into two categories: pharmacokinetics and pharmacodynamics.

    Pharmacokinetics: it involves biotransformation of the drug by body actions. There are four processes in which metabolism of the drug takes place that is absorption, distribution, metabolism and excretion.

    Absorption means how much administered drug reach into the bloodstream.

    Distribution tells the movement of the administered drug to various organs and tissues by the flow of the blood.

    Metabolism includes the degradation of drugs by using enzymes.

    Excretion comprises drug removal from the body.

    Pharmacodynamics: Action shown by the drug in the body after administration.

    Bioavailability: it is the measure of the extent of administered drug that is available to the systemic circulation in its original state.

    Applications:

    • It helps to collect data for clinical trials and use it for obtaining a new drug molecule.
    • It tells us about various interactions of drugs, side effect, and its therapeutic window.
    • Correlate whether two different drugs show the same effect or opposite which helps us to categorize drugs.
    • Provide assessment of the action of drugs on a diseased state or healthy patient.
    • It provides the most relevant data regarding the dose and dosage form.

    Disadvantage:

    • After so many trials, sometimes drug show interaction with other drugs, safety issues, AdRs which leads to withdrawal of molecules from the market.
    • It consumes much time to take a drug into the market due to clinical trials.
    • The low therapeutic index of the drug leads to a problematic condition.
    • Drug-drug interaction or drug polymorphism leads to degradation of the desired molecule and its therapeutic action.
    • Individualization of the dose is required but it can increase cost which is trouble to drug discovery of molecule.

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